I'M AN ORIGINAL CATCHPHRASE
A GAME-CHANGING TECHNOLOGY
SOUND INDUCED MORPHOGENESIS
Controlled remotely by acoustic waves, Sound Induced Morphogenesis (SIM) allows to pattern biological material such as cells, organoids, or tissue fragments into three-dimensional constructs that develop into engineered tissues, for example microvascular networks.
​
SIM is an exclusive process to reproduce the fundamental steps of nature’s design strategy: condensing bioactives and pattern formation control.
Patterning of living
building blocks
Cells, Spheroids, Organoids, Micrografts
Patterning of particles
Calcium phosphate, Hydrogel precursors, Polymer microbeads
Versatile
Controlled condensation and defined wide length scale, from micrometer to centimeter.
Gentle
Cell friendly, contact-less process that does not impair cell viability and metabolic activity.
Scalable
A process that speaks the industrial language.
FAST
Create multicellular architectures within seconds
CELL FRIENDLY
Contactless & mild process. Phenotype cell viability & metabolic activity preserved
SIMPLE
Create architectures of materials of choice with a large bank of sound profiles
CymatiX™
Our SIM-Discovery tool
Overcomes limitations
Creates physiologically relevant engineered tissue constructs and in vitro models
Allows full control
Overcome majors challenges by controlling cell density enhancement and pattern formation
Standalone & Compact
Compatible with any lab hood or biosafety cabinet
Customisable
Evolutive & upgradable architecture with cross linking, thermal management and predictive design tools
Applications
Publications
Engineering Sensory Ganglion Multicellular System to Model Tissue Nerve Ingrowth
Advanced Science (2023)
Discogenic pain is associated with deep nerve ingrowth in annulus fibrosus tissue (AF) of intervertebral disc (IVD). To model AF nerve ingrowth, primary bovine dorsal root ganglion (DRG) micro-scale tissue units...
Differential proteomics profile of microcapillary networks in response to sound pattern-driven local cell density enhancement
ScienceDirect (2024)
Spatial cell organization and biofabrication of microcapillary networks in vitro has a great potential in tissue engineering and regenerative medicine. This study explores the impact of...
Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing
ScienceDirect (2022)
The tumor microenvironment (TME), consisting of extracellular matrix, proteins, stromal cells, and a vascular system, is reported to have a key role in cancer progression and prognosis. Thereby, the interaction between...
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
Advanced Materials (2018)
Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that...
Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks
Biofabrication (2020)
Morphogenesis, a complex process, ubiquitous in developmental biology and many pathologies, is based on self-patterning of cells. Spatial patterns of cells, organoids, or inorganic particles can be forced on demand using acoustic surface standing waves, such as the Faraday waves.
Advanced Contactless Bioassembly Approaches: Leveraging Sound, Optical, and Magnetic Fields
Advanced NanoBiomed Research (2025)
The native structure of tissues and organs is characterized by a hierarchical architecture, where various cell types and extracellular matrix components are closely interconnected. The precise organization...
FastSkin® Concept: A Novel Treatment for Complex Acute and Chronic Wound Management
Journal of Clinical Medicine
Successful treatments for acute and chronic skin wounds remain challenging. The goal of this proof-of-concept study was to assess the technical feasibility and safety of a novel wound treatment solution, FastSkin®, in a pig model. FastSkin® was prepared from skin micrografts patterned in blood using acoustic waves.
Audible sound-controlled spatiotemporal patterns in out-of equilibrium systems
Nature Chemistry (2020)
Naturally occurring spatiotemporal patterns typically have a predictable pattern design and are reproducible over several cycles. However, the patterns obtained from artificially designed out-of-equilibrium chemical...